Down syndrome. They will have developmental delayed, speak slowly, have problems using their muscles. and have quite noticeable external characteristics such as a flat face, flat head, flat nose, small, oval eyes, short neck, shorter body than people of the same age when growing up and may have various health problems.

Abnormal symptoms mentioned above caused by an extra copy of chromosome 21 called Down syndrome, which occurs in approximately 1 in 800 to 1 in 1,000 of all births.

The risk will be more and more higher in older mothers. If you are over 35 years old your risk will increase to 1 in 250

The American College of Obstetrics and Gynecologist (ACOG) in 2007 recommend that all pregnant women who come for prenatal care before 20 weeks of pregnancy must receive advice on fetal screening for Down syndrome. Regardless of how old the woman is. and should be advised to understand the differences between Screening tests and diagnostic tests that are available to provide options. And offer prenatal diagnosis in cases where screening results are in a high risk group

cffDNA is produced and secreted from the placenta. It will increasing more and more according to the increasing gestational age. We can screen babies for chromosomal abnormalities from 10 weeks of gestation onwards.

This test can show risks of having one extra pair of chromosome (normally there are 23 pairs of chromosomes in the body) such as chromosome 21 causing Down syndrome, chromosome 18 causes Edwards syndrome and chromosome 13 causes Patua syndrome, etc., in addition to the 3 groups of symptoms mentioned above. Such examination can also detect other abnormalities caused by deficiency or excess of other pairs of chromosomes can also occur, such as Klinefelter’s syndrome where there is an abnormality of the sex chromosomes from XY to XXY and currently There is also the development of testing for these various diseases, increasing the testable diseases all the time.